**Recoverable Sample System (RSS)** capsule, an ingestible capsule designed for noninvasive collection of an intestinal fluid specimen while the capsule passes naturally through the gastrointestinal tract, developed by [[Biora Therapeutics]]. The RSS capsule is designed to recognize anatomical features within the GI tract and sample intestinal fluid at a pre-programmed, targeted location, such as the proximal large intestine. This precision sampling may be used to provide more insight on specific drug targets in the intestine. The study suggests that samples from distinct locations in the GI tract can be different from fecal samples and may offer unique insights into microbiome research, which can be advantageous in the development of precision therapeutics.